The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection
OBJECTIVES: FTY720 modulates CD4+T cells by the augmentation of regulatory T cell activity, secretion of suppressive cytokines and suppression of IL-17 secretion by Th17 cells.To further understand the process of graft rejection/acceptance, we evaluated SUPER skin allograft survival and associated events after FTY720 treatment.METHODS: F1 mice (C57